Finding out about the genetic makeup of an embryo may be helpful in trying to identify embryos which are more likely to lead to a healthy pregnancy. We are very proud that much of the early work in PGD (pre-implantation genetic diagnosis) was originally pioneered at our sister clinic at Hammersmith Hospital.

If you’d like to discuss the genetic diagnosis options available to you for your IVF cycle, please contact us.

Pre-Implantation Genetic Screening (PGS)

Chromosomal abnormality is one of the most common causes of unsuccessful pregnancy. If an embryo has too many or too few chromosomes (a condition called aneuploidy) this can have a serious effect on its chances of developing normally into a fetus and then a baby. In many cases, embryos with the wrong number of chromosomes stop growing by themselves, and this unfortunately often results in miscarriage.

This is no less common with IVF treatment. However, the IVF process enables us to monitor the development of multiple embryos at the same time. We can provide various levels of genetic screening during treatment, to help us select embryos with normal chromosomes, which have the best chance of developing into a healthy pregnancy.

The pre genetic screening we offer is Next Generation Sequencing from embryo biopsy.

How does PGS work?

The first few stages of an IVF cycle that involves PGS are no different from any other.

The embryos that develop will be examined and you will be advised if they are suitable for biopsy which will take place on day 5 or day 6. A small sample of cells (called a biopsy) within the embryo are taken using a needle. The sample of cells is called a biopsy and we make sure that we take this from the cells which will go onto make the placenta so that we do not damage the cells that will make the baby. The biopsy samples are placed in tubes and sent to the genetics laboratory. The genetic test takes 4 weeks to process so your embryos are frozen until we have the result.

Scientists working in the laboratory carry out the PGS test on all of the samples received. The test results indicate how many copies there are of each chromosome, revealing any abnormal embryos. PGS does not require additional blood tests prior to the IVF cycle. Once the results are known your follow up appointment will be confirmed.

PGD (Pre-implantation Genetic Diagnosis) with Karyomapping

 

At Boston Place, we are proud to offer PGD, one of the most cutting edge fertility services.

This is a very specific technique which can be used where a serious genetic disease which could be passed to offspring is to be avoided, and is only appropriate for couples known to be carriers of a genetic mutation.

By creating embryos in a similar way to ICSI treatment, a single cell or group of cells can be removed from an embryo and the genetic material contained in the cells chromosomes can be analysed to see if it carries that disease or not. The couples can be reassured their baby will not be affected by a severe genetic condition.

Very careful preparation is required before undertaking this form of treatment and may require blood sampling from family members.

If you are interested in this service, our specialist team will guide you through the steps required.

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