We are getting a new look and name but don’t worry the remarkable care is staying the same.

We are getting a new look and name but don’t worry the remarkable care is staying the same.

IVF and ICSI can be very successful treatment methods. However, some cycles don’t finish with successful implantation, even after a number of transfers with apparently good embryos. Also, sometimes a cycle achieves a conception, but the pregnancy doesn’t develop to term.

There are various biological reasons why these two circumstances could be related, which lead us to look at potential therapies which could help. We offer comprehensive investigations and tailor your treatment cycle accordingly.

Investigations and treatments

“Recurrent implantation failure” is sometimes defined as 2 or more failed embryo transfers in IVF/ICSI treatment cycles although there is no formal definition. However evidence from clinical trials is not conclusive. Listed below are options we can talk about in a follow-up appointment in the upsetting event of a failed cycle or miscarriage. In devising treatment programmes, there are investigations we can carry out before treatment starts, which help us to tailor your treatment closely to your needs. There are also options carried out in the process of treatment that could help implantation.

If you’d like to talk about your options after an implantation failure or miscarriage, we’re here to help.

  • Clotting (thrombophilia) screen – Small clots in the blood have been identified as a possible cause for a pregnancies failing to progress. In some cases this can be treated with aspirin, or heparin injections to thin the blood.
  • Immune screen – Increased levels of uterine natural killer cells (white cells) and autoantibodies (antibodies attacking specific organs) have also been suggested as a cause for repeated failure of cycles. The use of steroids, intralipids and other drugs to suppress the immune system and to help a pregnancy develop are controversial. More clinical trials are needed to understand the ways in which the immune system affects pregnancy and which treatments might benefit which women). Some of the drugs used in these treatments have side effects for both a mother and her developing baby, and it’s important to understand these risks before deciding with your doctor whether testing or treatment is recommended.
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Paternal factors

  • Sperm DNA fragmentation – Assessing the degree of damage to sperm DNA help identify those couples that would benefit from ICSI treatment.

Embryo factors

  • Genetic screening – We can use genetic screening to learn more about embryos before they are implanted, which helps us select the best embryos most likely to implant. Please see our genetic screening page for more information.
  • Time-lapse imaging – Recording information by time-lapse photography allows us to assess more subtle changes seen during embryo development and identify the best embryos for transfer.
  • Laser-assisted hatching – Assisted hatching is a physical or chemical treatment carried out immediately before embryo transfer. It weakens an area of the zona pellucida (the embryo’s ‘shell’) with the aim of improving the chances of implantation. We use a laser, as it is considered to be the safest and most accurate method.

Check out our latest news post

Fertility Treatment Update – 16th July 2021


Meet us at our next open event:

Thu 29 July

Boston Place IVF and Fertility Open Evening

Call us on +44 (0) 207 993 0870 |Or message us

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